What’s the difference between leopard gecko and fat tailed gecko? Leopard gecko and african fat-tailed gecko share the same subfamily “Eublepharidae”. Eublepharidae are a family of geckos lacking sticky pads on their toes (they have claws instead). They also have movable eyelids unlike other species of geckos. Aside from being in the same subfamily, leopard gecko and african fat-tailed are two different species from different parts of the world.